Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains
Amit Kumar Sahu, Alberto Minetti, Domenico Di Fraia, Antonio Marino, Patrick Rainer Winterhalter, Daniela Giustarini, Ranieri Rossi, Andreas Simm, Francesco Neri, Federico Galvagni, Christoph Gerhardt, Thorsten Pfirrmann, Alessandro Ori
This study shows oxidative stress reduces DUB activity in aging brains, which can be reversed with antioxidants, suggesting a reversible cause of proteostasis decline.
Nature Communications · Apr 21, 2026Peer-reviewedBiochemistry