A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on a heavy chain.
Alina G. Mikhailova, Alina A. Mikhailova, Kristina Ushakova, Evgenii O. Tretiakov, Dmitrii Iliushchenko, Victor Shamanskiy, Andrei Iurchenko, Marianna Zazhytska, Elena Kozenkova, Evgeny M. Zdobnov, Vsevolod J. Makeev, Valerian A. Yurov, M. Tanaka, Irina S. Gostimskaya, Zoë Fleischmann, , Konstantin Yu. Popadin
The paper identifies an AH>GH substitution signature in mtDNA linked to aging and TSSS, showing higher frequency in species with longer generation lengths.
bioRxiv · Dec 3, 2021 · PreprintBioinformatics