RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity
Shivendra Vikram Singh, Jie Fang, Hongjian Jin, Lee-Ann Van de Velde, Andrew Cortes, Jiani Chen, Sivaraman Natarajan, Evon Poon, Qiong Wu, Christopher L. Morton, Mary A. Woolard, Waise Quarni, Jacob A. Steele, Jon P. Connelly, Liusheng He, , Jun J.J. Yang
This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.
Nature Communications · Sep 17, 2025Peer-reviewedCancer Biology