Andrew Hill

Population genomics reveals multi-scale mechanisms sustaining schistosomiasis re-emergence in a near-elimination setting

The paper uses population genomics to analyze Schistosoma japonicum re-emergence in Sichuan, China, revealing a diverse parasite population maintained in reservoirs and a regional transmission network.

Sex differences in the genetic architecture of clinical quantitative traits in the electronic health record

The paper identifies sex-specific genetic loci for clinical traits using EHR data, finding that differential effect magnitudes, not opposing effects, dominate sex-specific genetic architecture.

Nutrient stress activates Rab5b-mediated autophagy to remodel the synaptic proteome

The paper shows nutrient stress activates Rab5b-mediated autophagy at synapses, leading to proteome remodeling, distinct from mTORC1 inhibition effects.

A Spatial Proteomic Atlas of Tertiary Lymphoid Structures in Non-Small Cell Lung Cancer Identifies a Novel Predictive Class of Lymphoid Aggregates

The paper identifies a novel class of mature lymphoid aggregates in NSCLC using spatial proteomics and develops a classifier to improve CPI biomarker eligibility.

Analysis of protein-coding genetic variation in 60,706 humans

This paper analyzes protein-coding genetic variation in 60,706 humans to catalog diversity, assess pathogenicity, and identify genes under strong selection.