Liu Yang

GeneEmbedLLM: Harnessing Large Language Models for Gene Functional Embedding and Association Prediction

This paper introduces GeneEmbedLLM, a framework using large language models to generate gene embeddings from multi-source textual annotations, achieving competitive performance in various downstream tasks.

Genetic disruption of cutaneous de novo glucocorticoid synthesis: a CRISPR-Cas9 CYP11B1-knockout human epidermal model

This paper creates a CRISPR-Cas9 CYP11B1-knockout human epidermal model to study the effects of blocking cutaneous glucocorticoid synthesis.

A direct RNA sequencing workflow for simultaneous profiling of tRNA abundance and modifications in mouse liver

This paper introduces a direct RNA sequencing workflow to profile tRNA abundance and modifications in mouse liver, identifying key modification sites and isotype-specific patterns.

Glutamine-regulated VCP acetylation creates a proteostasis vulnerability in RB1-deficient tumor

This study identifies VCP inhibition as a therapeutic strategy for RB1-deficient tumors by revealing glutamine-regulated VCP acetylation as a proteostasis vulnerability.

Population genomics reveals multi-scale mechanisms sustaining schistosomiasis re-emergence in a near-elimination setting

The paper uses population genomics to analyze Schistosoma japonicum re-emergence in Sichuan, China, revealing a diverse parasite population maintained in reservoirs and a regional transmission network.

Pathogenesis and immune responses to Eurasian avian like H1N1 and influenza D virus in pigs.

This study compares the pathogenesis and immune responses of EAavH1N1 and IDV in pigs, finding distinct viral kinetics and immune activation profiles.

Oncogene-induced senescence and senescence-associated secretory phenotype (SASP) determine the efficacy of palbociclib in PIK3CA mutated colorectal cancer

This study shows that PIK3CA mutations in colorectal cancer induce senescence and SASP, causing resistance to palbociclib, but combining it with erlotinib overcomes this resistance.

A Self-Assembling Immune-Featured Osteosarcoma Patient/PDX Derived Organoid Model and Biobank for Personalized Immune Therapy

The paper develops a patient/PDX-derived osteosarcoma organoid model and biobank to enable rapid testing of personalized immune therapies and drug development.

GWAS of ~30,000 samples with bone mineral density at multiple skeletal sites and its clinical relevance on fracture prediction, genetic correlations and prioritization of drug targets

This study performs GWAS on BMD traits and fracture risk using 30,000 UK Biobank samples, identifies novel loci, and prioritizes drug targets for osteoporosis prevention.

SEAD: an augmented reference panel with 22,134 haplotypes boosts the rare variants imputation and GWAS analysis in Asian population

The paper introduces SEAD, an Asian reference panel that improves rare variant imputation and GWAS analysis, identifying a novel association between SNTG1 and hip BMD.