Reliable and Efficient Agentic Protein Design with Toolset Harnessing
Jasper Butcher, Jie Chen, Andrew Hunt, Cyrus M. Haas, Wenzhao Dai, Shajesh Sharma, Raktim Mitra, Saman Salike, Jeremy G. Koob, Aiko Muraishi, Zhe Li, Harley Pyles, Michael Dominik Tyka, Magnus S. Bauer, Rafi I. Brent, , David Baker
Chaperone, a DataFrame-based framework and agent harness for protein design tools, cut tokens 86% and GPU-hours 64% while raising pass rate from 6% to 12%.
bioRxiv · Oct 20, 2026 · PreprintBiochemistry✦ In-depth digest