Jasper Butcher

This study designs de novo amide ligases with a cysteine catalytic triad to selectively form amide bonds across diverse substrates, demonstrating high selectivity and applicability in synthesizing bioactive molecules.

Chaperone, a DataFrame-based framework and agent harness for protein design tools, cut tokens 86% and GPU-hours 64% while raising pass rate from 6% to 12%.

This paper designs sequence-specific DNA binding proteins using deep learning, achieving a 100-fold improvement in success rates over previous methods.

An all-atom diffusion model using a 14-atom residue representation and sparse U-Net architecture accelerates biomolecular design 10-fold, enabling experimentally validated DNA-binding proteins and multi-turnover cysteine hydrolases.

AtomWorks, a modular atom-level data framework, trains structure prediction and design models; the resulting RF3 improves chirality handling and performs between AF3 and Boltz.