The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway
Hao Chen, Cole Ferguson, Dylan Charles Mitchell, Isabel Risch, Amanda Titus, João A. Paulo, Andrew Hwang, L. P. Beck, Tsen‐Hsuan Lin, Wei Jun Gu, Sheng‐Kwei Song, Carla M. Yuede, Hiroko Yano, Obi L. Griffith, Malachi Griffith, , Albert H. Kim
This study shows that USP7 deletion in mice causes neurological phenotypes, including synaptic proteome changes and dendritic spine defects, independent of p53.
Cell Reports · Jan 23, 2025Peer-reviewedNeuroscience