Age-related biological dysregulation quantified using metabolomics is composed of distinct subsystems with synergistic associations to health outcomes: An analysis of the Canadian Longitudinal Study on Aging
Hesam Hafezalseheh, Michael Chong, Alan A Cohen, Guillaume Pare, Andrew Rutenberg, Vanessa Taler, Dawn ME Bowdish, Chris P Verschoor
The paper quantifies age-related biological dysregulation using metabolomics in older adults and shows it has distinct subsystems linked to health outcomes and DNA methylation.
bioRxiv · Nov 3, 2026 · PreprintPhysiology