Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex
Jenna Houff, Andrew Williams, Obie Allen, Barbara Gisabella, Harry Pantazopoulos, Alberto Del Arco
This study shows psilocybin reduces reward-seeking behavior and increases activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex in rats.
bioRxiv · Dec 26, 2025 · PreprintNeuroscience