rat

Dual kinase inhibition provides early clues to restoration of neuroimmune homeostasis in an AAV-haSyn model of Parkinsons disease

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

Shikonin alleviates bone cancer pain through suppression of spinal IGF2-associated p38 MAPK signaling

This study shows that intrathecal Shikonin reduces bone cancer pain in rats by suppressing spinal IGF2-associated p38 MAPK signaling, improving pain-related behaviors and reducing inflammation.

ER stress-associated IRE1α signalling links impaired QPRT-dependent NAD⁺ biosynthesis to reduced oocyte competence

This study links ER stress and impaired NAD biosynthesis via QPRT to reduced oocyte quality and shows that NMN supplementation improves oocyte function and early embryonic development.

Residual Hearing Loss After Chronic Cochlear Implantation in Guinea Pigs is Primarily Conductive

This study identifies middle ear dysfunction as the primary cause of residual hearing loss in chronically implanted guinea pigs, suggesting a conductive mechanism.

Neonatal NMDA receptor blockade disrupts prefrontal cortical regulation of social affective behavior: implications for schizophrenia

This study shows that neonatal NMDA receptor blockade impairs social affective behavior in rats, linked to reduced parvalbumin interneurons in the medial prefrontal cortex.

Deep transcriptomic analysis of molecular mediators of complex traits in heterogeneous stock (HS) rats

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

Early AAV9-mediated SLC9A6 gene replacement preserves cerebellar structure and motor function in the shaker rat model of Christianson syndrome

This study evaluates AAV9-mediated SLC9A6 gene replacement in shaker rats, showing early treatment preserves cerebellar structure and motor function, while later treatment has diminishing effects.

Hide and seek in a rainforest canopy : when a fruit-eating carnivore (almost) met its top predator carnivore

The paper describes a rare observation of a nocturnal arboreal kinkajou being followed by a puma in a rainforest canopy.

Sex differences in agonistic social behavior: Effects of exercise and ovariectomy

This study examines how sex, exercise, and ovariectomy affect offensive and defensive aggression in rats, finding sex-specific behavioral differences and no effect of exercise.

Therapeutic Potential of Melatonin, Erythropoietin, and TRPV4 Antagonism in a Preclinical Model of Genetic Hydrocephalus

This study evaluates a triple therapy of erythropoietin, melatonin, and TRPV4 antagonist in a rat model of congenital hydrocephalus, showing reduced ventricular expansion and inflammation.

Extended Pavlovian conditioned approach training and devaluation in Long-Evans rats using time-restricted feeding

This study develops an extended Pavlovian conditioned approach paradigm in Long-Evans rats under time-restricted feeding to better identify phenotypes linked to compulsive behaviors and stress-related dysregulation.

Sex-specific gene and isoform expression characterizes hippocampal aging in rhesus macaques

This study identifies sex-specific gene and isoform expression changes in hippocampal aging of rhesus macaques and finds shared transcriptional signatures with Alzheimer's disease.

Title: Combinatorial bnAb and T Cell Immunization Enhances Post-Infection Control of SHIVSF162p3 Viremia in Rhesus Macaques

This study shows that combining broadly neutralizing antibodies with T cell immunization improves post-infection control of SHIVSF162p3 viremia in rhesus macaques.

A microstructural analysis of water intake patterns associated with light phase food and water restriction in male and female rats.

The paper examines how food and water intake patterns in rats change under light phase restrictions, finding that food access timing more strongly influences water intake than water access timing influences food intake.

Gut Stem Cell Secretome Therapy Promotes Durable Neuroprotection and Functional Recovery After Stroke

This study shows that intestinal epithelial stem cell secretome improves gut repair and cognitive outcomes after stroke in male rats but not in female rats, highlighting the need for sex-specific therapies.

The collective effect of non-nicotine constituents on the reinforcing and neuropharmacological effects of comprehensive cigarette smoke and electronic nicotine delivery system (ENDS) aerosol extracts in rats.

This study compares the reinforcing and neuropharmacological effects of cigarette smoke and e-cigarette aerosol extracts with nicotine in rats, finding that non-nicotine constituents in cigarette smoke contribute to these effects.

SQANTI-evidence: isoform-resolved, evidence-tiered structural annotation of unannotated genomes from long-read RNA-seq

SQANTI-evidence annotates genomes from long-read RNA-seq without a reference, achieving high precision in gene and isoform prediction across species.

Inosine Triphosphate Pyrophosphatase as a Candidate Associated with White Matter Abnormalities in Chronic Heart Failure

This study identifies inosine triphosphate pyrophosphatase (ITPA) as a candidate factor linking chronic heart failure and white matter abnormalities through human, animal, and cellular analyses.

Where single-cell foundation models help: a benchmark of annotation, perturbation and regulatory inference against simple baselines

This paper benchmarks single-cell foundation models against baselines for annotation, perturbation and regulatory inference using diverse datasets.

Mechanisms of impaired cerebral hemodynamics and memory resilience differ by sex: A role for mineralocorticoid receptors in VCID

This study investigates sex-specific effects of hypertension on cerebral hemodynamics and memory, finding that MR antagonism improves perfusion and memory in female rats but not males.

Multi-faceted role of dopamine afferents to the ventral pallidum in reward processing

This study investigates the role of dopamine afferents to the ventral pallidum in reward processing using circuit tracing, fibre photometry, and behavioural pharmacology in male rats.

Distinct patterns of multisensory integration underly the expression of flavor preferences and aversions in rats

This study shows that rats integrate taste and smell signals differently depending on the valence of flavor components, challenging the MLE framework for multisensory integration.

An Innate Neuroprotective Reflex Activates NRF2 via Phosphorylation of p62 at Ser351 to Mitigate Traumatic Brain Injury

This paper shows that artificial diving reflex via trigeminal nerve stimulation activates NRF2 through p62 phosphorylation, offering neuroprotection in traumatic brain injury without depleting antioxidant reserves.

Recruitment of intrasegmental and propriospinal interneuron networks of forelimb motor circuitry in chronic cervical contusion spinal cord injury

This study shows that PTEN inhibition improves forelimb motor recovery and circuit remodeling in chronic cervical SCI by enhancing spinal interneuron network recruitment and synaptic input.

Physical sensorimotor contingencies facilitate learning in monkeys

This study shows that rhesus monkeys learn maze-solving tasks significantly faster in a physical environment than in a virtual one, with limited performance transfer between the two.

Long-term dysregulation of histone acetylation, BDNF expression, and the hippocampal transcriptome in adult rats exhibiting a depressive-like phenotype following repeated chlorpyrifos exposure

This study shows that repeated chlorpyrifos exposure in rats leads to long-term epigenetic and transcriptional changes in the hippocampus, including reduced BDNF and altered neuronal plasticity pathways, associated with a depressive-like phenotype.

Amyloid/RNA Condensates with Germ Granule Characteristics Are Present in Rat Epididymal Spermatozoa and Exhibit Prion-Like Propagation Activity

The paper identifies germ granule-like amyloid/RNA condensates in rat epididymal spermatozoa that exhibit prion-like propagation activity, suggesting a non-Mendelian mechanism for transmitting environmental information to offspring.

Dyskinesia induced by a dopamine 2 receptor-like agonist, but not a dopamine 1 receptor-like agonist, is blocked by sub-anesthetic ketamine

This study shows that sub-anesthetic ketamine reduces dyskinesia caused by D2R-like receptor agonists but not D1R-like receptor agonists in L-DOPA-primed rats.

Species-specific WNT requirements shape somite morphogenesis in mammalian embryo models

This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.

Reaction-time asymmetry covaries with shifts in hand choice in macaques

This study shows that macaque hand choice and reaction time are influenced by target position, hand displacement, head rotation, and gaze direction, similar to human behavior.