APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease
Rachel Ee, Meelad Amouzgar, Jumana Afaghani, Kausalia Vijayaragavan, Bryan J. Cannon, Dunja Mrdjen, Dmitry Tebaykin, Angie Spence, Cathrine Sant, David Aley, Zhongyi Guo, Kamilla Sedov, Faria Zafar, Kathleen S. Montine, Amalia Perna, , Sean C. Bendall
This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.
bioRxiv · Jun 19, 2026 · PreprintImmunology