Author

Cathrine Sant

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:machine learning (classical)· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Ryan CorcesiD· 3 shared Jorge J. PalopiD· 2 shared Lennart MuckeiD· 2 shared Pranav NambiariD· 2 shared Reuben ThomasiD· 2 shared Stephanie R. MilleriD· 2 shared Zhongyi Guo· 2 shared Amalia PernaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

M. Ryan CorcesORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

Sara J. Knowles, Cathrine Sant, Pranav Nambiar, Rafaella Araujo Gonçalves, Kaitlyn Ho, Gui-Qiu Yu, Reuben Thomas, Megumi Mori, Lane Domke, Victor Huang, Nicholaus A. Smith, Iris Lo, Stephanie R. Miller, M. Ryan Corces, Jorge J. Palop, Lennart Mucke

This study shows that reducing tau mitigates transcriptomic and behavioral issues in an Alzheimer's model without affecting amyloid levels.

bioRxiv · Aug 4, 2026 · PreprintNeuroscience

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease

Rachel Ee, Meelad Amouzgar, Jumana Afaghani, Kausalia Vijayaragavan, Bryan J. Cannon, Dunja Mrdjen, Dmitry Tebaykin, Angie Spence, Cathrine Sant, David Aley, Zhongyi Guo, Kamilla Sedov, Faria Zafar, Kathleen S. Montine, Amalia Perna, , Sean C. Bendall

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

bioRxiv · Jun 19, 2026 · PreprintImmunology

APOE4-Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation in preclinical Alzheimer's disease

Jia Shin, Erica S Brady, Chun Chen, Kelli Lauderdale, Ayushi Agrawal, Yutong Zhang, Xueqiao Jiang, Pranav Nambiar, Jessica Herbert, Dakota D. Mallen, Katie K. Ly, Patrick S. Honma, Zhongyi Guo, Cathrine Sant, Reuben Thomas, , Jorge J. Palop

This study investigates how APOE4 and Aβ interact in preclinical Alzheimer's disease, finding their synergistic effects on neuronal proteostasis and network dysfunction.

bioRxiv · Nov 11, 2025 · PreprintNeuroscience

CHOIR improves significance-based detection of cell types and states from single-cell data

Cathrine Sant, Lennart Mucke, M. Ryan Corces

CHOIR improves cell type and state detection in single-cell data by using statistical inference to assess clustering results, outperforming existing methods across multiple data types.

Nature Genetics · Apr 7, 2025Peer-reviewedBioinformatics