Methionine synthase reductase regulates heterochromatin independently of methionine synthesis through mitochondrial homeostasis
Fernanda Rezende Pabst, Andrey Tvardovskiy, Iratxe Estibariz, Veronica Finazzi, Pauline Couacault, Anna Artati, Michael A. Witting, Antonio Scialdone, Till Bartke, Robert Schneider, Daphne S. Cabianca
This study shows that MTRR-1 regulates heterochromatin through mitochondrial homeostasis, not methionine synthesis, in C. elegans.
bioRxiv · Aug 10, 2026 · PreprintCell Biology