Author

Anna Doetsch

Swiss Tropical and Public Health Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Sébastien GagneuxiD· 5 shared Sònia BorrelliD· 5 shared Galo Adrián GoigiD· 4 shared Selim BouaouinaiD· 4 shared Valerie F. A. MarchiD· 4 shared Miriam Reinhard· 3 shared Sevda Kalkan· 3 shared Chloé LoiseauiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersMicrobiology

Sébastien GagneuxORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Within-host evolution of drug tolerance in Mycobacterium tuberculosis.

Valerie F. A. March, Kakha Mchedlishvili, Galo Adrián Goig, Nino Maghradze, Teona Avaliani, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Selim Bouaouina, Anna Doetsch, Sevda Kalkan, Miriam Reinhard, Sébastien Gagneux, Sònia Borrell

This study investigates how antibiotic tolerance evolves in Mycobacterium tuberculosis during treatment and finds no evidence that it contributes to delayed culture conversion.

JAC-Antimicrobial Resistance · Jan 7, 2026Peer-reviewedMicrobiology

Variability in intrinsic drug tolerance in Mycobacterium tuberculosis corresponds with phylogenetic lineage

Valerie F. A. March, Michaela Zwyer, Chloé Loiseau, Daniela Brites, Galo Adrián Goig, Selim Bouaouina, Anna Doetsch, Miriam Reinhard, Sevda Kalkan, Sébastien Gagneux, Sònia Borrell

The paper measures drug tolerance in Mycobacterium tuberculosis lineages and finds higher tolerance in L3 and L4 strains, with heritable patterns and enrichment of mutations in specific metabolic pathways.

Antimicrobial Agents and Chemotherapy · Oct 21, 2025Peer-reviewedMicrobiology

Epistasis between drug resistance-conferring mutations in Mycobacterium tuberculosis

Selim Bouaouina, Sònia Borrell, Jérôme Azizaj, Thomas Bock, Amanda J Ross, Chloé Loiseau, Sevda Kalkan, Miriam Reinhard, Valerie F. A. March, Anna Doetsch, Alexander Schmidt, Amir Banaei‐Esfahani, Sébastien Gagneux

The paper shows that epistatic interactions between RpoB and GyrA mutations in Mycobacterium tuberculosis can lead to high-fitness double-resistant strains, which are prevalent in clinical isolates.

bioRxiv · Aug 7, 2025 · PreprintMicrobiology

Large contribution of repeats to genetic variation in a transmission cluster of Mycobacterium tuberculosis

Christoph Stritt, Michelle Reitsma, A Marin, Galo Adrián Goig, Anna Doetsch, Sònia Borrell, Christian Beisel, Iñaki Comas, Daniela Brites, Sébastien Gagneux

The paper characterizes repeat-associated mutations in Mycobacterium tuberculosis genomes using long-read sequencing, revealing their significant contribution to genetic variation in an outbreak.

Microbial Genomics · May 1, 2025Peer-reviewedGenomics

Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis.

Valerie F. A. March, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Selim Bouaouina, Anna Doetsch, Galo Adrián Goig, Sébastien Gagneux, Sònia Borrell

The paper shows that antibiotic treatment affects Mycobacterium tuberculosis culturability, with differential effects on colony formation and liquid culture growth.

Scientific Reports · Jan 28, 2025Peer-reviewedMicrobiology