Author
Swiss Tropical and Public Health Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Christoph Stritt, Chloé Loiseau, Sevda Kalkan, Sònia Borrell, Daniela Brites, Sébastien Gagneux
The paper analyzes the evolutionary dynamics of IS6110 in Mycobacterium tuberculosis complex strains using ancestral state reconstruction and identifies patterns of insertion and selection.
bioRxiv · Sep 29, 2026 · PreprintGenomics
Valerie F. A. March, Kakha Mchedlishvili, Galo Adrián Goig, Nino Maghradze, Teona Avaliani, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Selim Bouaouina, Anna Doetsch, Sevda Kalkan, Miriam Reinhard, Sébastien Gagneux, Sònia Borrell
This study investigates how antibiotic tolerance evolves in Mycobacterium tuberculosis during treatment and finds no evidence that it contributes to delayed culture conversion.
JAC-Antimicrobial Resistance · Jan 7, 2026Peer-reviewedMicrobiology
Galo Adrián Goig, Chloé Loiseau, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Ana Tsutsunava, Daniela Brites, Sevda Kalkan, Sònia Borrell, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Sébastien Gagneux
This study identifies patient and bacterial factors associated with unfavorable tuberculosis treatment outcomes in Georgia using genomic and clinical data from 4,536 patients.
Genome Medicine · Nov 14, 2025Peer-reviewedGenetic & Genomic Medicine
Valerie F. A. March, Michaela Zwyer, Chloé Loiseau, Daniela Brites, Galo Adrián Goig, Selim Bouaouina, Anna Doetsch, Miriam Reinhard, Sevda Kalkan, Sébastien Gagneux, Sònia Borrell
The paper measures drug tolerance in Mycobacterium tuberculosis lineages and finds higher tolerance in L3 and L4 strains, with heritable patterns and enrichment of mutations in specific metabolic pathways.
Antimicrobial Agents and Chemotherapy · Oct 21, 2025Peer-reviewedMicrobiology
Selim Bouaouina, Sònia Borrell, Jérôme Azizaj, Thomas Bock, Amanda J Ross, Chloé Loiseau, Sevda Kalkan, Miriam Reinhard, Valerie F. A. March, Anna Doetsch, Alexander Schmidt, Amir Banaei‐Esfahani, Sébastien Gagneux
The paper shows that epistatic interactions between RpoB and GyrA mutations in Mycobacterium tuberculosis can lead to high-fitness double-resistant strains, which are prevalent in clinical isolates.
bioRxiv · Aug 7, 2025 · PreprintMicrobiology