Cooperativity between Ras pathway mutations in colonic tumorigenesis
Christian William Johnson, Anna Idelevich, Bing Shui, Alison W. Tisdale, Eve O’Donoghue, Joshua Cook, Shannon Hull, Moon Hee Yang, Shikha Sheth, Elizabeth M. Terrell, Stefânia Bovo Minto, Deborah K. Morrison, Scott Kopetz, Rona D. Yaeger, Kevin M. Haigis
This study shows that specific KRAS mutations, like A59E, cooperate with other genetic alterations in CRC and affect response to EGFR inhibitors.
bioRxiv · Sep 5, 2025 · PreprintCancer Biology