Single-Cell and Tissue-Specific CRISPR Editing Analyses Unveil New Insights to Off-Targets and Translocations
Alexandra Madsen, Niklas Selfjord, Marta Martínez-Lage, Anna-Lena Loyd, Gavin Kurgan, Mikaela Stahlberg, Julia Lindgren, Julia Liz Touza, Leif Wigge, Mike A. Firth, Karl J. V. Nordström, Joseph Collin, Daniel Jachimowicz, Bastian Schiffthaler, Inken Dillmann, , Pınar Akçakaya
The paper analyzes CRISPR-Cas9 off-target mutations and translocations at single-cell and tissue-specific levels in mice, revealing context-dependent variability in editing outcomes.
bioRxiv · Jun 10, 2026 · PreprintGenomics