Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer
Mathéa Géraud, Rémi Gence, Anne Casanova, Estelle Clermont, Simona Salimbeni, Nesibe Özsu, Maïna Vienne, Célia Delahaye, Elodie Borrull, Amélie Lusque, Mathilde Morisseau, Thomas Filleron, Delphine Pagan, Camille Taha, Agnese Cristini, , Olivier Sordet
The paper shows that persistent TOP1 cleavage complexes in drug-tolerant lung cancer cells drive adaptive resistance to EGFR-targeted therapies by promoting mutagenesis and reveals TDP1 loss as a targetable vulnerability.
Science Advances · Sep 23, 2026Peer-reviewedMolecular Biology