Author

Elodie Borrull

Centre National de la Recherche Scientifique

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:human· 1

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Agnese CristiniiD· 1 shared Amélie LusqueiD· 1 shared Anne Casanova· 1 shared Anne PradinesiD· 1 shared Camille Taha· 1 shared Célia DelahayeiD· 1 shared Delphine PaganiD· 1 shared Estelle Clermont· 1 shared

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1 shared paperMolecular Biology

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1 paper

Recent·Most cited

Molecular BiologyScience AdvancesPeer-reviewedSep 23, 2026

Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer

Mathéa Géraud, Rémi Gence, Anne Casanova…·Olivier Sordet

The paper shows that persistent TOP1 cleavage complexes in drug-tolerant lung cancer cells drive adaptive resistance to EGFR-targeted therapies by promoting mutagenesis and reveals TDP1 loss as a targetable vulnerability.

DOI 10.1126/sciadv.aeh9099

humanexperimental assay

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