Immunoproteasome deficiency results in accelerated brain aging and epilepsy
Hanna Leister, Felix F. Krause, Beatriz Gil, Ruslan Prus, Inna Prus, Anne Hellhund, Meghma Mitra, Rogério R. Gerbatin, Norman Delanty, Alan Beausang, Francesca M. Brett, Michael A. Farrell, Jane Cryen, Donncha F. O’Brien, David Clifford Henshall, , Tobías Engel
This study shows that immunoproteasome deficiency accelerates brain aging and causes epilepsy in mice, with reduced immunoproteasome expression also observed in human epilepsy patients.
bioRxiv · Mar 30, 2023 · PreprintNeuroscience