Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesia
Otmane Bouchatta, Anne Marshall, S. Lindström, Jussi Kupari, Houria Manouze, Ahmed Barakat, Huasheng Yu, Ilona Szczot, J. Johansson, Rolf B. Saager, Max Larsson, Wenqin Luo, Andrew G. Marshall, Patrik Ernfors, Håkan Olausson, , NIH PRECISION Human Pain Network
The paper shows that TRPV1+ afferents rapidly reprogram TRPV1- Aβ afferents, leading to hyperalgesia in humans.
bioRxiv · Feb 8, 2026 · PreprintNeuroscience