J. Johansson

Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesia

The paper shows that TRPV1+ afferents rapidly reprogram TRPV1- Aβ afferents, leading to hyperalgesia in humans.

SPIRO - the automated Petri plate imaging platform designed by biologists, for biologists

SPIRO automates Petri plate imaging for plant phenotyping, improving precision and enabling dark condition assays with open-source accessibility.

Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

This study shows that the Bri2 BRICHOS domain inhibits α-synuclein oligomer formation and toxicity by suppressing secondary nucleation and binding oligomers, suggesting its potential as a therapeutic target for Parkinson's disease.

ALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to ATR inhibition

This study identifies ALK signaling's role in enhancing DNA damage response in neuroblastoma, showing that combined ATR/ALK inhibition leads to sustained tumor response and differentiation.

Heat inactivation of foetal bovine serum causes protein contamination of extracellular vesicles

This study shows that heat inactivating fetal bovine serum after EV depletion contaminates EV samples with bovine proteins, leading to misattribution in proteomic analyses.

A grappling hook interaction balances self-assembly and chaperone activity of Nucleophosmin 1

The paper investigates how NPM1 self-assembly and chaperone activity interact, finding that oligomerization modulates its ability to prevent amyloid formation.

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

Mapping trait versus species turnover reveals spatiotemporal variation in functional redundancy in a plant-pollinator network

The paper examines how trait turnover within species affects functional redundancy and network vulnerability in an Arctic bumblebee-plant pollination network across elevation and season.

Absolute quantification and single-cell dose-response of cytosolic siRNA delivery

The paper develops a confocal microscopy method to quantify cytosolic siRNA delivery at the single-cell level and identifies dose-response relationships for knockdown efficiency.

A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

Structural basis of resistance to lincosamide, streptogramin A, and pleuromutilin antibiotics by ABCF ATPases in Gram-positive pathogens

The paper determines the structures of ARE ABCF-ribosome complexes from three Gram-positive bacteria and proposes a model for antibiotic resistance mechanisms.

RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.

This study shows RAL GTPases activate EGFR/MAPK signaling in intestinal stem cells, promoting proliferation and tumorigenesis, but are independent of oncogenic RAS.

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

The paper identifies BET inhibitors as potential cardio-protective drugs that block inflammation-induced cardiac dysfunction and SARS-CoV-2 infection in pre-clinical models.