Spatial architecture of complex antibody formats dictates pharmacokinetics via FcRn-recycling
Stefan C Weise, Cordula Jany, Sabine Imhof-Jung, Claire Simonneau, Johannes Fraidling, Anna-Lena Bolender, Aman Padamsey, Elisa Di Lenarda, Anne Christine Cascais, Thomas Emrich, Tilman Schlothauer, Annette Indlekofer, Hubert Kettenberger, Volker Haucke, Wolfgang F. Richter, Thomas E. Kraft
This study shows how antibody structure affects FcRn recycling and pharmacokinetics, finding that invertbody design reduces clearance by threefold.
bioRxiv · Nov 4, 2026 · PreprintPharmacology & Toxicology