A multi-omic integrative scheme characterizes tissues of action at loci associated with type 2 diabetes
Jason Torres, Moustafa Abdalla, Anthony Payne, Juan J. Fernandez-Tajes, Matthias Thurner, Vibe Nylander, Anna L. Gloyn, Anubha Mahajan, Mark I. McCarthy
The paper develops a framework to determine tissue-of-action for type 2 diabetes GWAS signals by integrating gene expression and epigenomic data, revealing key tissues and enhancing functional interpretation.
The American Journal of Human Genetics · Nov 12, 2020Peer-reviewedGenetics