Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages
Paula Martínez-Oca, Arnaud Meng, Quentin Vanbellingen, Marvin Albert, Antoine Thomas, Perrine Bomme, Francisco Javier García-Rodríguez, COSIPOP study group, Jean-Yves Tinévez, Sandrine Aros-Calt, Carmen Buchrieser, Pedro Escoll
This study uses single-cell metabolomics to show that Legionella pneumophila infection induces metabolic reprogramming in human macrophages, with bacterial effectors promoting glycolytic shifts.
bioRxiv · Sep 3, 2026 · PreprintMicrobiology