Francisco Javier García-Rodríguez

This study uses single-cell metabolomics to show that Legionella pneumophila infection induces metabolic reprogramming in human macrophages, with bacterial effectors promoting glycolytic shifts.

This study shows Salmonella can replicate in macrophages without Type III Secretion Systems if provided with preferred nutrients, highlighting the role of host metabolic heterogeneity in bacterial replication.

This study identifies RidL as a bifunctional effector that inhibits retrograde trafficking and promotes mitochondrial fragmentation by phosphorylating Drp1, aiding Legionella pneumophila's intracellular survival.

This study identifies Complex I as essential for maintaining mitochondrial membrane potential during infection with virulent bacteria, revealing distinct strategies used by Legionella and Salmonella.

The paper tracks metabolic dynamics in single human macrophages infected with Legionella pneumophila to predict bacterial replication with 83% accuracy using machine learning.

This study identifies SifA as a key effector that prevents Salmonella dormancy by promoting nutrient accessibility through SIF-mediated remodeling of the Salmonella-containing vacuole.

This study identifies a unique capsule in Legionella longbeachae that enhances intracellular replication and immune evasion, distinguishing it from other Legionella species.

This paper investigates how 2-deoxyglucose (2DG) induces endocytosis of plasma membrane proteins in yeast, revealing a role for the Snf1/AMPK pathway and Rod1 in mediating 2DG resistance.