Polymerase Eta Recruits FANCD2 to Common Fragile Sites to Maintain Genome Stability
Mrunmai Niljikar, Angelica Barreto-Galvez, Saloni Patel, Julia Elizabeth Gagliardi, Vasudha Kumar, Archana Pradeep, Aastha Juwarwala, Jeannine Gerhardt, Yoke‐Chen Chang, Cristina Montagna, Advaitha Madireddy
This study shows that polymerase Eta's PIP and UBZ domains are critical for managing replication stress at common fragile sites by recruiting FANCD2 and preventing DNA damage.
bioRxiv · Jan 6, 2025 · PreprintMolecular Biology