Filament assembly confers the mechanical resilience of the IFI16 restrictosome
Christina M. Stallings, Archit Garg, Jungsan Sohn
This study shows that IFI16 filament assembly provides mechanical stability to condensates by compacting DNA into ultra-stable tangles, contrasting with the sensitivity of HIN200-dsDNA complexes.
bioRxiv · Nov 2, 2026 · PreprintBiophysics