Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation.
Akanksha Jain, Rico Dong, Jana Kroll, Jack F. Webster, Jon Moss, Arthur Bikbaev, Sila K. Ultanir, Alfredo Gonzalez‐Sulser, Christian Rosenmund, Martin Heine, Jian Liu, Michael Alan Cousin, Daniela Ivanova
This paper shows that presynaptic filopodia, driven by activity, calcium, and actin, physically modulate membrane mechanics to enhance synchronous neurotransmission and contribute to seizure generation.
Science Advances · Oct 28, 2026Peer-reviewedNeuroscience