Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks
Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki‐Wullich, Nina Lannette-Weimann, Naďa Majerníková, Arthur Grenon, Vance Difan Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, , Jean‐Charles Lambert
This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.
bioRxiv · Apr 29, 2024 · PreprintNeuroscience