Engineered RVG29-Conjugated Chitosan for Enhanced Brain Delivery of Kisspeptin Agonists and Antagonists in Reproductive Health.
A Irfan, Kiran Kumar P, Stuti Bhagat, Reena Yadav, Divya Mehta, Anjali Kumari, Aditya D. Deshpande, Bhuvan Bhaskar Tripathi, Y Silambarasan, Mohd Athar, Ananya Aeri, Arvind Sonewane, Vikash Chandra, Sanjay K. Singh, H. B. D. Prasada Rao, G. Taru Sharma
This paper develops a brain delivery system using RVG29-conjugated chitosan nanoparticles to deliver kisspeptin agonists and antagonists, showing enhanced brain accumulation and effective modulation of reproductive functions.
bioRxiv · Oct 26, 2025 · PreprintBioengineering