Epigenetic Context Defines the Transcriptional Activity of Canonical and Noncanonical NF-κB Signaling in Pancreatic Cancer
Joana E. Aggrey-Fynn, Joshua Busch, Dominik Saul, Ashish Rajput, Kerstin Willecke, Meghana Manjunath, Nicole Klimt, Kothai Rajendran, Nadine Schacherer, Wanwan Ge, Julia Thiel, Amro Abdelrahman, Mark Joseph Truty, Meng Dong, Steven A. Johnsen
This study identifies TNF and TWEAK as activators of canonical and noncanonical NF-κB signaling in PDAC, revealing distinct epigenetic dependencies of RELA and RELB.
Cell Death Discovery · Mar 17, 2026Peer-reviewedCancer Biology