Dominik Saul

This study identifies IL-17A's role in enhancing T-cell viability through mitochondrial complex I in CTCL, suggesting therapeutic targeting of this pathway.

SenoQuant is an AI software for analyzing and predicting senescence markers in tissues, offering spatial quantification across imaging modalities and supporting custom models.

This study shows that both intrinsically disordered and structured domains of the Progesterone Receptor are required for transcriptional condensate formation and regulate distinct gene expression programs.

This study identifies TNF and TWEAK as activators of canonical and noncanonical NF-κB signaling in PDAC, revealing distinct epigenetic dependencies of RELA and RELB.

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

The paper uses GSEA to analyze the transcriptome of HL-60/S4 macrophages, identifying senescence-related gene sets and phenotypic changes.

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.