IGF-1 from bone marrow Adipoq-lineage cells stimulates endocortical bone formation in mature female mice
J. Bertels, Jasmin Koehnken Sawall, Brian M. Dulmovits, Xiaobin Liu, Ashley Phan, Xing Ji, Fangfang Song, Christopher S. Thom, Fanxin Long
The paper identifies Adipoq+ stromal cells in bone marrow as a source of IGF-1 that promotes endocortical bone formation in mature female mice without affecting trabecular bone or hematopoiesis.
JBMR Plus · Feb 14, 2026Peer-reviewedDevelopmental Biology