Triazole Stress Induces Accelerated Degradation of Aspergillus fumigatus Hmg1
Jinhong Xie, Adela Martín‐Vicente, Harrison I. Thorn, Uxue Perez‐Cuesta, Asmita Nandi, Jarrod R. Fortwendel
This study shows triazole antifungals induce Hmg1 degradation in Aspergillus fumigatus through lanosterol accumulation, and pharmacologically enhancing this mechanism improves triazole efficacy.
bioRxiv · Oct 3, 2026 · PreprintMicrobiology