Jarrod R. Fortwendel

This study shows triazole antifungals induce Hmg1 degradation in Aspergillus fumigatus through lanosterol accumulation, and pharmacologically enhancing this mechanism improves triazole efficacy.

This study uses TurboID to identify septation regulators in A. fumigatus by analyzing proximity labeling data of SIN components, revealing new genes involved in septum formation and cell wall stress tolerance.

This study shows that macrophage ferroptosis impairs Aspergillus killing in lung transplant recipients, increasing fungal infection risk.

This study identifies the maiA gene in Aspergillus fumigatus as critical for cell wall homeostasis and virulence through in vitro and in vivo experiments.

This paper identifies Erg6 as an essential gene for viability in Aspergillus species and shows its importance in fungal infection models.

This study uses genome-wide association analysis to identify genetic loci associated with itraconazole sensitivity in Aspergillus fumigatus clinical isolates, finding two SNPs linked to susceptibility and validating one through CRISPR/Cas-9 knockout.