Molecular glue degraders of CK1α remodel lysosomes and limit ferroptosis in glioblastoma stem-like cells
Jane Jardine, Margaux Le Guyon, Kilian Trillet, Audrey Lacquemant, Isabelle Verdu, Talha Sagheer, Laura Merlet, Rosalie Moreau, Gwennan André‐Grégoire, Mathilde Kerhervé, François Guillonneau, Guillaume Bastiat, Nicolas Bidère
This study identifies CK1 as a regulator of lysosomal fitness and ferroptotic sensitivity in glioblastoma stem-like cells through molecular glue degraders.
bioRxiv · Oct 27, 2026 · PreprintCancer Biology