Author

Laura Merlet

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

François GuillonneauiD· 2 shared Gwennan André‐GrégoireiD· 2 shared Jane JardineiD· 2 shared Kilian TrilletiD· 2 shared Nicolas BidèreiD· 2 shared Rosalie Moreau· 2 shared Alice BoissardiD· 1 shared Audrey Lacquemant· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

François GuillonneauORCID

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2 papers

Recent·Most cited

Molecular glue degraders of CK1α remodel lysosomes and limit ferroptosis in glioblastoma stem-like cells

Jane Jardine, Margaux Le Guyon, Kilian Trillet, Audrey Lacquemant, Isabelle Verdu, Talha Sagheer, Laura Merlet, Rosalie Moreau, Gwennan André‐Grégoire, Mathilde Kerhervé, François Guillonneau, Guillaume Bastiat, Nicolas Bidère

This study identifies CK1 as a regulator of lysosomal fitness and ferroptotic sensitivity in glioblastoma stem-like cells through molecular glue degraders.

bioRxiv · Oct 27, 2026 · PreprintCancer Biology

The Kinase CK1α coordinates Initiation and Termination of the cGAS-STING Pathway

Jane Jardine, Marine Tarrillon, Gwennan André‐Grégoire, Kilian Trillet, Vanessa Josso, Laura Merlet, Rosalie Moreau, Célia Jaunasse, Luc Antigny, Séverine Marionneau‐Lambot, François Guillonneau, Alice Boissard, Cécile Henry, Joanna Re, Sophie Barillé‐Nion, , Nicolas Bidère

This study identifies CK1 as a bimodal regulator of the cGAS-STING pathway, showing it both promotes DNA sensing and facilitates signaling termination, with therapeutic implications for cancer.

Cell Death and Differentiation · Aug 5, 2026Peer-reviewedImmunology