The paper examines T-cell receptor sequence diversity and HLA alleles in Midwestern Amish participants to explore associations with Alzheimer's disease and cognitive status.

Annals of Human Genetics · Oct 18, 2026Peer-reviewedGenetic & Genomic Medicine

Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish

Yining Liu, Yeunjoo E. Song, Weihuan Wang, Audrey Lynn, Kristy L. S. Miskimen, Sarada L. Fuzzell, Sherri D. Hochstetler, Reneé A. Laux, Dawn Miller, Penelope L. Miron, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herinton, Ping Wang, Alex V. Gulyayev, , Jonathan L. Haines

The paper estimates heritability and identifies genetic variants, including rare ones, associated with Alzheimer disease in the Amish population.

medRxiv · Sep 20, 2026 · PreprintGenetic & Genomic Medicine

Heritability of Age-Related Macular Degeneration in the Amish

Noel C. Moore, Yeunjoo E. Song, Alex V. Gulyayev, Kristy L. S. Miskimen, Penelope L. Miron, Reneé A. Laux, Audrey Lynn, Sarada L. Fuzzell, Sherri D. Hochstetler, Dawn Miller, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herington, Ping Wang, Yining Liu, , Jonathan L. Haines

This study estimates the heritability of age-related macular degeneration in the Amish population using SNP and pedigree-based methods, finding substantial genetic contributions.

medRxiv · Aug 6, 2026 · PreprintGenetic & Genomic Medicine

Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries

Diya Yang, Y. Yang, Nicholas R. Ray, Mengxuan Li, Penelope H. Benchek, Dana C. Crawford, John F. O’Toole, John R. Sedor, Christiane Reitz, Audrey Lynn, Xiaofeng Zhu, Jonathan L. Haines, William S. Bush

This paper identifies shared genetic loci between kidney function and Alzheimer disease across ancestries, revealing both horizontal and vertical pleiotropy with APOE as the only shared locus.

medRxiv · Apr 6, 2026 · PreprintGenetic & Genomic Medicine

Heritability of Alzheimer-related plasma biomarkers in the Amish population

Ping Wang, Yeunjoo E. Song, Audrey Lynn, Kristy L. S. Miskimen, Alex V. Gulyayev, Michael B. Prough, Daniel A. Dorfsman, Reneé A. Laux, Sarada L. Fuzzell, Sherri D. Hochstetler, Andrew F. Zaman, Larry Deon Adams, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herington, , Jonathan L. Haines

The paper estimates heritability of Alzheimer-related plasma biomarkers in the Amish population, finding moderate genetic contributions to biomarker variances.

medRxiv · May 13, 2025 · PreprintGenetic & Genomic Medicine