The paper examines T-cell receptor sequence diversity and HLA alleles in Midwestern Amish participants to explore associations with Alzheimer's disease and cognitive status.

Annals of Human Genetics · Oct 18, 2026Peer-reviewedGenetic & Genomic Medicine

Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish

Yining Liu, Yeunjoo E. Song, Weihuan Wang, Audrey Lynn, Kristy L. S. Miskimen, Sarada L. Fuzzell, Sherri D. Hochstetler, Reneé A. Laux, Dawn Miller, Penelope L. Miron, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herinton, Ping Wang, Alex V. Gulyayev, , Jonathan L. Haines

The paper estimates heritability and identifies genetic variants, including rare ones, associated with Alzheimer disease in the Amish population.

medRxiv · Sep 20, 2026 · PreprintGenetic & Genomic Medicine

Heritability of Age-Related Macular Degeneration in the Amish

Noel C. Moore, Yeunjoo E. Song, Alex V. Gulyayev, Kristy L. S. Miskimen, Penelope L. Miron, Reneé A. Laux, Audrey Lynn, Sarada L. Fuzzell, Sherri D. Hochstetler, Dawn Miller, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herington, Ping Wang, Yining Liu, , Jonathan L. Haines

This study estimates the heritability of age-related macular degeneration in the Amish population using SNP and pedigree-based methods, finding substantial genetic contributions.

medRxiv · Aug 6, 2026 · PreprintGenetic & Genomic Medicine

Heritability of Alzheimer-related plasma biomarkers in the Amish population

Ping Wang, Yeunjoo E. Song, Audrey Lynn, Kristy L. S. Miskimen, Alex V. Gulyayev, Michael B. Prough, Daniel A. Dorfsman, Reneé A. Laux, Sarada L. Fuzzell, Sherri D. Hochstetler, Andrew F. Zaman, Larry Deon Adams, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herington, , Jonathan L. Haines

The paper estimates heritability of Alzheimer-related plasma biomarkers in the Amish population, finding moderate genetic contributions to biomarker variances.

medRxiv · May 13, 2025 · PreprintGenetic & Genomic Medicine

Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets

Jairo D. Ramos, Laura J. Caywood, Michael B. Prough, Jason E. Clouse, Sharlene D. Herington, Susan H. Slifer, M. Denise Fuzzell, Sarada L. Fuzzell, Sherri D. Hochstetler, Kristy L. S. Miskimen, Leighanne R. Main, Michael D. Osterman, Owen Laframboise, Andrew F. Zaman, Patrice L. Whitehead, , William K. Scott

The paper identifies three SNVs associated with delayed age at onset of cognitive impairment in Amish populations, with one replicated in an independent dataset and linked to the SHISA6 gene.

Alzheimer s & Dementia · May 1, 2022Peer-reviewedGenetic & Genomic Medicine