Glycan-coated nanoparticles mimicking the ischemic glycocalyx scavenge the complement system conferring protection after experimental ischemic stroke
Gizem Erol, Serena Seminara, Domenico Mercurio, Aurora Bianchi, Alessia Porta, Chantal Dembech, Patricia Perez Schmidt, Laura Polito, Claudia Durall, Franca Orsini, Luana Fioriti, Davide Comolli, Massimiliano De Paola, Gianluigi Forloni, Maria-Grazia De Simoni, , Stefano Fumagalli
The paper demonstrates that glycan-coated nanoparticles can sequester complement lectin pathway components, reducing ischemic brain injury in a mouse model.
bioRxiv · Apr 1, 2026 · PreprintNeuroscience