Lung endothelial niche signaling governs self-renewal and fate transitions of human alveolar stem cells
Bang-Jin Kim, Dasom Hwang, Jimyung Park, Sung Joo Jang, Jaewon Kim, Chiara Camillo, Elena Floris, Austin Choi, Soomin Ryu, Frank D’Ovidio, Sandra W. Ryeom
This study identifies a lung endothelial niche that regulates human alveolar stem cell self-renewal and differentiation through MAPK and YAP signaling, showing its role in alveolar regeneration.
bioRxiv · Mar 9, 2026 · PreprintCell Biology