Author

Austin Tedman

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Charles P. KuntziD· 3 shared Jonathan P. SchlebachiD· 3 shared Catherine Foye· 2 shared Eli Fritz McDonaldiD· 2 shared JaNise J Jackson· 2 shared Jens MeileriD· 2 shared Joseph Paul RobinsoniD· 2 shared Kathryn E. OliveriD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersBiochemistry

Charles P. KuntzORCID

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Author profile →

3 papers

Recent·Most cited

Profiling the CFTR Variant Selectivity and Off-Target Interactions of VX-121

Ashish R. Jhangiani, John A. Olson, Austin Tedman, Catherine Foye, JaNise J Jackson, Ashlyn G Winters, J Renfrew White, Mia Perfetti, Grace M Abell, Crissey D. Cameron, Liudmyla Arifova, Brianna Corman, J. Paul Robinson, Charles P. Kuntz, Kaitlyn V. Ledwitch, , Jonathan P. Schlebach

This study evaluates VX-121's efficacy across 232 rare CFTR variants, finding it generally more effective than VX-445 but with one variant showing reduced selectivity.

bioRxiv · Jun 8, 2026 · PreprintPharmacology & Toxicology

Deep Receptor Scanning Reveals General Sequence Constraints on GPCR Biosynthesis

Austin Tedman, Muskan Goel, Sohan Shah, Mathew K. Howard, Laura M. Chamness, Antonio Bonifasi, Ismalia Adams, Jacklyn M. Gallagher, Wesley D. Penn, Katarina Nemec, Eli Fritz McDonald, Brianna N. Corman, Joseph Paul Robinson, Carol Beth Post, Patricia L. Clark, , Jonathan P. Schlebach

The paper introduces a platform to characterize GPCR expression and uses machine learning to identify structural features affecting their biosynthesis.

bioRxiv · Sep 19, 2025 · PreprintBiochemistry

General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants

Austin Tedman, John A Olson, Minsoo Kim, Catherine Foye, JaNise J Jackson, Eli Fritz McDonald, Andrew G. McKee, Karen Noguera, Charles P. Kuntz, Jens Meiler, Kathryn E. Oliver, Lars Plate, Jonathan P. Schlebach

This study investigates how calnexin modulates the expression and pharmacological rescue of CFTR variants using deep mutational scanning, revealing its role in CFTR assembly and variant-specific corrector responses.

bioRxiv · Apr 3, 2025Biochemistry