Jonathan P. Schlebach

This study investigates how ribosome-mediated protein folding imposes sequence constraints by analyzing mutations in E. coli DHFR using deep mutational scanning and fluorogenic sensors.

The paper shows that translocon remodeling affects ribosomal frameshifting and viral polyprotein maturation in alphaviruses, reducing viral fitness.

This study evaluates VX-121's efficacy across 232 rare CFTR variants, finding it generally more effective than VX-445 but with one variant showing reduced selectivity.

The paper identifies how protein stability, turnover, and abundance influence the connectivity of protein-protein interaction networks in yeast.

ANYI integrates yeast PPI data with sixteen biophysical and regulatory annotations to enable cross-layer interactome analysis.

The paper shows that nascent polypeptide feedback triggers ribosomal frameshifting and transcript decay through specific motifs and splicing events.

The paper introduces a platform to characterize GPCR expression and uses machine learning to identify structural features affecting their biosynthesis.

This study investigates how calnexin modulates the expression and pharmacological rescue of CFTR variants using deep mutational scanning, revealing its role in CFTR assembly and variant-specific corrector responses.

This study benchmarks AlphaMissense's ability to predict pathogenicity of CFTR missense variants using clinical and functional metrics, finding moderate correlations with some outcomes but limited utility for pharmacological response.

The paper examines how mutations in unstable membrane proteins like GnRHR form distinct epistatic interactions depending on their destabilizing mechanisms and severity.