Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance
Matthew T. Klope, Poulami Talukder, Brian R. Blank, Sevil Chelebieva, Jun Chen, Shaun D. Fontaine, Ryan L. Gonciarz, Priyadarshini Jaishankar, Grace J. Lee, Jennifer Legac, Vineet Mathur, Avani Narayan, Martin Okitwi, Stephen Orena, Nicholas S. Settineri, , Adam R. Renslo
The paper describes the discovery of new antimalarial trioxolanes effective against artemisinin-resistant parasites and their potential as development candidates for malaria treatment.
Science Advances · Aug 8, 2025Peer-reviewedPharmacology & Toxicology