Author

Stephen Orena

Infectious Diseases Research Collaboration

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:plant (other)· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Martin OkitwiiD· 3 shared Karamoko NiaréiD· 2 shared Melissa D. ConradiD· 2 shared Philip Jon RosenthaliD· 2 shared Abhai Tripathi· 1 shared Adam R. RensloiD· 1 shared Adoke YekaiD· 1 shared Alejandro McCotter-Gonzalez· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Martin OkitwiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Plasmodium falciparum PX1 haplotype is associated with reduced susceptibility to artemisinin and lumefantrine

Christopher Bower-Lepts, Arvind Jangra, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Alejandro McCotter-Gonzalez, Linda Romano, Stephen Orena, Martin Okitwi, Karamoko Niaré, Philip Joseph Rosenthal, Melissa D. Conrad, Photini Sinnis, Sachel Mok

This study identifies a PX1 haplotype in Plasmodium falciparum associated with reduced susceptibility to artemisinin and lumefantrine, providing a marker for drug resistance surveillance.

bioRxiv · Sep 9, 2026 · PreprintMicrobiology

Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

Matthew T. Klope, Poulami Talukder, Brian R. Blank, Sevil Chelebieva, Jun Chen, Shaun D. Fontaine, Ryan L. Gonciarz, Priyadarshini Jaishankar, Grace J. Lee, Jennifer Legac, Vineet Mathur, Avani Narayan, Martin Okitwi, Stephen Orena, Nicholas S. Settineri, , Adam R. Renslo

The paper describes the discovery of new antimalarial trioxolanes effective against artemisinin-resistant parasites and their potential as development candidates for malaria treatment.

Science Advances · Aug 8, 2025Peer-reviewedPharmacology & Toxicology

A novel locus associated with decreased susceptibility of Plasmodium falciparum to lumefantrine and dihydroartemisinin has emerged and spread in Uganda

Karamoko Niaré, Bersabeh Tafesse, Mayland Treat, Jacob M. Sadler, Martin Okitwi, Stephen Orena, Victor Asua, Oriana Kreutzfeld, Jenny Legac, Jacob Marglous, Samuel L. Nsobya, Adoke Yeka, Dave Richard, Michael T. Ferdig, Angana Mukherjee, , Melissa D. Conrad

bioRxiv · Jul 30, 2025 · PreprintGenomics