Comparative molecular analysis of histopathologic subtypes reveals shared epithelial remodeling yet distinct fibroblast programs in scleroderma lung disease
Monica M. Yang, Vincent C Auyeung, Seon Min C Kim, Emily Flynn, Ram Prasad Naikawadi, Alexey V. Bazarov, Averey Lea, Fred Deiter, Jessica Neely, Jasleen Kukreja, Michael A. Matthay, Kirk D. Jones, John R. Greenland, Marina Sirota, Paul J. Wolters
This study compares molecular features of SSc-NSIP and SSc-UIP with IPF, finding shared epithelial changes and distinct fibroblast programs.
bioRxiv · Nov 4, 2026 · PreprintGenomics