A systematic imputation framework for sparse, multimodal space biology datasets: application to retinal imaging and omics from the RR9 mission
Vaishnavi Nagesh, Lauren Sanders, Sylvain V. Costes, Pinar Avci, Ayse Sigit, Amey Agarwal, Alireza Hayati, Alavia Batool, Fathi Karouia, Atul Munish Chander, Caleb M. Schmidt, Jian Gong
The paper presents a framework for imputing sparse, multimodal space biology datasets and shows that MICE-Elastic and a hybrid strategy preserve biological signal better than other methods.
bioRxiv · Jun 11, 2026 · PreprintBioinformatics