Molecular Studies of Phages-Klebsiella pneumoniae in a Mucoid Environment: Innovative use of mucolytic agents prior to the administration of lytic phages
O. Pacios, L. Blasco, C. Ortiz-Cartagena, I. Bleriot, L. Fernandez-Garcia, M. Lopez, A. Barrio-Pujante, A. Pascual, F. Fernandez-Cuenca, L. Martinez-Martinez, B. Aracil, J. Oteo-Iglesias, M. Tomas
This study shows that mucin promotes phage resistance in K. pneumoniae, but mucolytic agents like NAC reduce this resistance, suggesting their potential use in phage therapy.
bioRxiv · Aug 2, 2023 · PreprintMicrobiology